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Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
- Source :
- FEBS Letters; Dec2005, Vol. 579 Issue 30, p6885-6889, 5p
- Publication Year :
- 2005
-
Abstract
- Abstract: We have earlier reported overexpression of the central and peripheral cannabinoid receptors CB1 and CB2 in mantle cell lymphoma (MCL), a B cell non-Hodgkin lymphoma. In this study, treatment with cannabinoid receptor ligands caused a decrease in viability of MCL cells, while control cells lacking CB1 were not affected. Interestingly, equipotent doses of the CB1 antagonist SR141716A and the CB1/CB2 agonist anandamide inflicted additive negative effects on viability. Moreover, treatment with the CB1/CB2 agonist Win-55,212-2 caused a decrease in long-term growth of MCL cells in culture. Induction of apoptosis, as measured by FACS/Annexin V–FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL. [Copyright &y& Elsevier]
- Subjects :
- LYMPHOMAS
CELL death
DEATH (Biology)
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 579
- Issue :
- 30
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19185788
- Full Text :
- https://doi.org/10.1016/j.febslet.2005.11.020