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Vascular Protection in Brain Ischemia.
- Source :
- Cerebrovascular Diseases; May2006 Supplement 2, Vol. 21, p21-29, 9p, 2 Diagrams
- Publication Year :
- 2006
-
Abstract
- Vascular damage occurring after cerebral ischemia may lead to a worse outcome in patients with ischemic stroke, as it facilitates edema formation and hemorrhagic transformation. There are several phases in the development of vascular injury (acute, subacute and chronic) and different mediators act in each one. Therapeutic options to avoid vascular injury must be focused on acting in each phase. However, even though experimental studies have demonstrated the benefit of therapeutic interventions both in the acute and chronic phases of cerebral ischemia, only the chronic phase offers a therapeutic window sufficiently wide enough to provide vascular protection in clinical practice. Several drugs including erythropoietin and HMG-CoA reductase inhibitors (statins), antihypertensive (angiotensin modulators), antibiotics (minocycline) and antihyperglycemic drugs (thiazolidinediones) have been proved to provide vascular protection in patients with ischemic stroke. Anti-inflammatory, antioxidant, and antiapoptotic actions are responsible for the vascular protective effect related to these drugs. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- CEREBRAL ischemia
CEREBROVASCULAR disease
EDEMA
DRUG therapy
ERYTHROPOIETIN
Subjects
Details
- Language :
- English
- ISSN :
- 10159770
- Volume :
- 21
- Database :
- Complementary Index
- Journal :
- Cerebrovascular Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20655545
- Full Text :
- https://doi.org/10.1159/000091700