Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout.

Presents a study which found that hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific insulin-like growth factor-1 receptor (IGF-1R) knockout (LIGFREKO). Efficient inactivation of IGF-1R gene in hepatocytes of LIGFREKO mice; Alteration of liver regeneration in LIGFREKO mice; Conclusions and significance of the study.