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FOXP3 Identifies Regulatory CD25brightCD4+ T Cells in Rheumatic Joints.

Authors :
Cao, D.
Börjesson, O.
Larsson, P.
Rudin, A.
Gunnarsson, I.
Klareskog, L.
Malmström, V.
Trollmo, C.
Source :
Scandinavian Journal of Immunology; Jun2006, Vol. 63 Issue 6, p444-452, 9p, 1 Chart, 5 Graphs
Publication Year :
2006

Abstract

Regulatory T cells have recently been implicated in a number of human diseases, including rheumatoid arthritis. To investigate whether the presence of CD25<superscript>+</superscript>CD4<superscript>+</superscript> regulatory T cells is a general finding in arthritic joints, synovial fluid of patients with different rheumatic diseases such as undifferentiated arthritides, systemic rheumatic diseases and reactive arthritis were investigated for the presence of such cells. In 95% of the patients, a higher frequency of CD25<superscript>bright</superscript>CD4<superscript>+</superscript> T cells was found in synovial fluid as compared with peripheral blood. Both in vitro suppression experiments and FOXP3 mRNA analysis confirmed these cells to be natural regulatory T cells. Together with our previous data, we conclude that arthritic joints, irrespective of precise diagnosis and disease duration, are enriched with natural regulatory T cells. These results suggest that suppressor cells migrate to and/or multiply at the sites of inflammation as part of the immune responses' effort to combat injurious inflammation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009475
Volume :
63
Issue :
6
Database :
Complementary Index
Journal :
Scandinavian Journal of Immunology
Publication Type :
Academic Journal
Accession number :
20986163
Full Text :
https://doi.org/10.1111/j.1365-3083.2006.001755.x