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Relation between aortic stiffness and coronary flow reserve in patients with coronary artery disease.

Authors :
Fukuda, D.
Yoshiyama, M.
Shimada, K.
Yamashita, H.
Ehara, S.
Nakamura, Y.
Kamimori, K.
Tanaka, A.
Kawarabayashi, T.
Yoshikawa, J.
Source :
Heart; Jun2006, Vol. 92 Issue 6, p759-762, 4p, 1 Chart, 2 Graphs
Publication Year :
2006

Abstract

Objectives: To investigate the relation between aortic stiffness and coronary flow reserve (CFR) in patients with coronary artery disease (CAD). Design: Observational study. Setting: Coronary care unit of a primary care hospital. Patients: 192 consecutive patients who underwent coronary angiography. Main outcome measure: Brachial-ankle pulse wave velocity (ba-PWV), CFR, and severity of CAD. Results: According to the angiographic findings, patients were divided into four subgroups: patients without significant stenosis (normal coronary artery (NCA) group, n = 28) and those with one vessel disease (1VD group, n = 92), no vessel disease (2VD group, n = 50), or three vessel disease (3VD group, n = 22). ba-PWV increased with the number of diseased vessels and was significantly correlated with the number of diseased vessels (NCA group v 1VD group v 2VD group v 3VD group: 1481 (252) v 1505 (278) v 1577 (266) v 1727 (347) cm/s, p < 0.001). CFR had a significant negative correlation with ba-PWV (r = -0.45, p < 0.0001 ). The diastolic to systolic velocity ratio obtained in 45 patients also was significantly correlated with ba-PWV (r = -0.35, p < 0.05). Multiple regression analysis showed that ba-PWV was an independent determinant of CFR (p < 0.01). Conclusions: Coronary flow is altered with aortic stiffening in patients with CAD. These results suggest one possible mechanism for recent reports that aortic stiffness is a key cardiovascular risk factor. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13556037
Volume :
92
Issue :
6
Database :
Complementary Index
Journal :
Heart
Publication Type :
Academic Journal
Accession number :
21078391
Full Text :
https://doi.org/10.1136/hrt.2005.067934