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Deficient Transendothelial Migration of Leukocytes in Q Fever: The Role Played by Interleukin-10.
- Source :
- Journal of Infectious Diseases; 8/1/2006, Vol. 194 Issue 3, p365-369, 5p
- Publication Year :
- 2006
-
Abstract
- Chronic Q fever is characterized by deficient cell-mediated immune response, lack of granulomas, and dysregulation of the cytokine network. Altered transendothelial migration(TM) of peripheral-blood mononuclear cells might account for impaired immune response. TM of lymphocytes and monocytes was decreased in patients with Q fever endocarditis, compared with that in patients recovering from acute Q fever and in control subjects. This defect is related to interleukin (IL)—10, a cytokine involved in the chronic evolution of the disease; neutralizing anti—IL-10 antibodies corrected TM of mononuclear cells from patients with Q fever endocarditis. IL-10 may account for deficient protective immunity in patients with Q fever endocarditis by impairing TM. [ABSTRACT FROM AUTHOR]
- Subjects :
- Q fever
CHRONIC diseases
INTERLEUKIN-10
RICKETTSIAL diseases
INTERLEUKINS
PNEUMONIA
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 194
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21544285
- Full Text :
- https://doi.org/10.1086/505227