Back to Search
Start Over
Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India.
- Source :
- International Journal of STD & AIDS; Jan2000, Vol. 11 Issue 1, p49-51, 3p, 1 Chart, 1 Graph
- Publication Year :
- 2000
-
Abstract
- Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS. Serum IL-10 levels were significantly higher after 6 months of follow up (P=0.01), while CD4 counts declined at a rate of 280 cells/ul per year, roughly 3 times the rate of decline reported for HIV+ asymptomatic subjects in developed countries. Changes in serum IL-10 levels and CD4 counts fell short of statistically significant correlation (P=0.1). Among AIDS patients in this cohort, the mean period from diagnosis of AIDS to death was <5 months and is in agreement with an earlier report of rapid progression in India. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV-positive persons
T cells
INTERLEUKIN-10
SERUM
Subjects
Details
- Language :
- English
- ISSN :
- 09564624
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 22202501
- Full Text :
- https://doi.org/10.1258/0956462001914904