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Synthesis of Tadalafil Analogues.

Authors :
Wang, Liu‐Tang
Huang, Hao
Ye, Zhong‐Lin
Wu, Yong
Wang, Xue‐Chao
Source :
Synthetic Communications; 2006, Vol. 36 Issue 18, p2627-2632, 6p
Publication Year :
2006

Abstract

Five novel compounds as potential phosphodiesterase type 5 (PDE‐5) inhibitors were synthesized from D‐tryptophan methyl ester via the Pictet–Spengler reaction and cyclization reaction. The structures of those compounds were confirmed by elemental analyses, IR, 1 H NMR, and ESI‐MS spectra. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00397911
Volume :
36
Issue :
18
Database :
Complementary Index
Journal :
Synthetic Communications
Publication Type :
Academic Journal
Accession number :
22391691
Full Text :
https://doi.org/10.1080/00397910600764626