Hepatocyte transplantation for metabolic liver disease: UK experience.

The article focuses on the use of hepatocyte transplantation for patients with metabolic liver disease in Great Britain. It also discusses the sources of hepatocytes, the isolation process, preclinical studies and clinical experience, especially in the treatment of liver-based inborn errors of metabolism. The outcome of hepatocyte transplantation would benefit from methods to enhance engraftment and subsequent repopulation of the liver, although the options for this in man will be limited.