INTERNALIZATION AND RECYCLING PATHWAY OF RAT SOMATOSTATIN RECEPTOR SUBTYPE 3.

Authors :: Kreuzer, O. J.
Schäfer, J.
Roosterman, D.
Déry, O.
Bunnett, N. W.
Meyerhof, W.
Source :: Journal of Neurochemistry; Jul99 Supplement, Vol. 73, pS139-S139, 1/4p
Publication Year :: 1999
Abstract: The article presents an abstract of the study "Internalization and Recycling Pathway of Rat Somatostatin Receptor Subtype 3." Researchers in the study elongated somatostatin receptor subtype 3 (sst3) at its C-terminus with HSV glycoprotein D or EGFP epitopes. Results of the study suggest that internalization of SST-14/sst3 complexes propagates through the clathrin pathway leading to degradation of somatostatin in acidic vesicles and recycling of sst3 to the plasma membrane.