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Whole-Blood Interleukin-18 Level during Early HIV-1 Infection Is Associated with Reduced CXCR4 Coreceptor Expression and Interferon-γ Levels.
- Source :
- Journal of Infectious Diseases; 3/1/2007, Vol. 195 Issue 5, p734-738, 5p
- Publication Year :
- 2007
-
Abstract
- Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERLEUKINS
HIV
ENDOTOXINS
INTERFERONS
ANTIRETROVIRAL agents
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 195
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23883845
- Full Text :
- https://doi.org/10.1086/511435