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Protease inhibitors reduce mitogen induced lymphocyte stimulation.
- Source :
- Immunology; Apr79, Vol. 36 Issue 4, p811-813, 3p
- Publication Year :
- 1979
-
Abstract
- Proteolytic events might play a role during lymphocyte activation. Mouse spleen cells were therefore stimulated in serum-free cultures by PHA, ConA, LPS and dextran sulphate and the effect of various added protease inhibitors on [³H]-thymidine incorporation investigated. Both soybean inhibitor and Trasylol inhibited the response of the cells to all mitogens. The other inhibitors (antipain, leupeptin, ovomucoid, alpha-1 trypsin, alpha-2 macroglobulin) had little or no effect. The marked inhibitory effect of tosyl-lysine chloromethylketone could be neutralized by reduced glutathione, indicating an effect on intracellular glutathione rather than on proteases. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEASE inhibitors
MITOGENS
LYMPHOCYTES
PROTEOLYTIC enzymes
SPLEEN
LABORATORY mice
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 36
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23941770