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Genetic determination of the immune response in mice to cells of different histological type.
- Source :
- Immunology; Apr79, Vol. 36 Issue 4, p835-841, 7p
- Publication Year :
- 1979
-
Abstract
- The intensity of the cellular immune response to strong transplantation antigens of the H-2 complex is related to the histological type of cells taken for immunization. Splenic cells from C3H mice immunized BALB/c mice better than cells of non-lymphoid origin from the same donor. The reverse was observed when, instead of BALB/c mice, C57B1/6 and A/He were used in immunization experiments. Analysis of the inheritance of this immunization pattern studied in mice of the first generation from various crosses between strains (BALB/c, C57B1/6 and A/He) and in mice from backcrosses has demonstrated that this immunization pattern is not inherited as a simple Mendelian character. Therefore, it could be supposed that efficiency of immunological control of cells having different histological types, may be genetically determined. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
LABORATORY mice
ANTIGENS
IMMUNIZATION
CELLS
HISTOPATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 36
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23941773