DIPEPTIDYLE PEPTIDASE IV/CD26 AND ADENOSINE DEAMINASE DURING IMMUNE RESPONSE AT RATS.

The dynamics of Dipeptidyl peptidase IV (DPPIV/CD26), a marker of activated T cells, and of Adenosine deaminase (ADA) during immunity development in rats were studied. Rats were immunized with human red blood cells (HRBC) intraperitoneally. DPPIV and ADA activities, as well as IgG and IgM titers were monitored during 30 days after immunization. We have described the dynamics of the enzymes activities and antibodies appearances. More over some similarities between immunoglobulins and enzymes development during immune response were found. Experimental data let us to suggest the possibility of participation of ADA in Th2 immunity and DPP IV in Th2 and Th1 immunity. [ABSTRACT FROM AUTHOR]