Different Types of Renal Dysfunction in Patients with Acute Myocardial Infarction Treated with Percutaneous Coronary InterventionDifferent Types of Renal Dysfunction in Patients with Acute Myocardial Infarction Treated with Percutaneous Coronary Intervention

Background: The prognostic significance of different types of renal dysfunction in patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) has not been well characterized. Methods: The single-center AMI registry encompassed 1,486 consecutive AMI patients treated with PCI, who were followed by mean 29.7 months. Subjects with an estimated glomerular filtration rate <60 mL/min per 1.73m² at baseline were selected (n = 283, 19.0%) and incorporated into the chronic kidney disease (CKD) group. The control group consisted of 1,203 subjects with normal renal function (81.0%). The CKD patients were divided into subgroups: with contrast-induced nephropathy – CKD + CIN (n = 68, 4.6%) and without – CKD–CIN (n = 215, 14.5%). Results: Remote mortality rate was significantly higher in CKD group (34.6%) and in particular subgroups: CKD + CIN (47.0%), CKD–CIN (31.0%) than in controls (9.1%, P < 0.001 for all study groups vs controls). Multivariate analysis identified CKD as an independent predictor of any-cause death in the whole population (hazard ratio [HR] 1.77, 95% confidence interval [CI] 1.60–1.94, P < 0.001). Similarly, CKD + CIN contrary to CKD–CIN had significant and independent influence on remote survival in study population (HR 2.16, 95% CI 1.95–2.37, P < 0.001). Conclusions: CKD and its types have significant, negative influence on long-term survival in AMI patients treated with PCI. It is especially strongly expressed in those CKD patients who develop contrast-induced nephropathy, which occurrence is an independent risk factor of mortality associated with over twofold increase of death hazard. [ABSTRACT FROM AUTHOR]