Back to Search
Start Over
Histone H2AX phosphorylation is associated with most meiotic events in grasshopper.
- Source :
- Cytogenetic & Genome Research; 2007, Vol. 116 Issue 4, p311-315, 5p, 2 Color Photographs
- Publication Year :
- 2007
-
Abstract
- It is widely accepted that the H2AX histone in its phosphorylated form (γ-H2AX) is related to the repair of DNA double-strand breaks (DSBs). In several organisms, γ-H2AX presence has been demonstrated in meiotic processes such as recombination and sex chromosome inactivation during prophase I (from leptotene to pachytene). To test whether γ-H2AX is present beyond pachytene, we have analysed the complete sequence of changes in H2AX phosphorylation during meiosis in grasshopper, a model organism for meiotic studies at the cytological level. We show the presence of phosphorylated H2AX during most of meiosis, with the exception only of diplotene and the end of each meiotic division. During the first meiotic division, γ-H2AX is associated with i) recombination, as deduced from its presence in leptotene-zygotene over all chromosome length, ii) X chromosome inactivation, since at pachytene γ-H2AX is present in the X chromosome only, and iii) chromosome segregation, as deduced from γ-H2AX presence in centromere regions at first metaphase-anaphase. During second meiotic division, γ-H2AX was very abundant at most chromosome lengths from metaphase to telophase, suggesting its possible association with the maintenance of chromosome condensation and segregation. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- HISTONES
PHOSPHORYLATION
MEIOSIS
GENETIC recombination
CELL division
GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 14248581
- Volume :
- 116
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Cytogenetic & Genome Research
- Publication Type :
- Academic Journal
- Accession number :
- 24676021
- Full Text :
- https://doi.org/10.1159/000100416