Herpes Simplex Virus Type 2 Infection Does Not Influence Viral Dynamics during Early HIV-1 Infection.

Objective. We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)—seropositive and —seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California. Design. The study was a retrospective cohort analysis. Methods. We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1—3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry. Results. We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log₁₀ copies/mL; P =.39 ) and early infection (4.57 vs. 4.67 log₁₀ copies/mL; P = .5). Longitudinally, the difference in HIV-1 loads between HSV-2—seropositive and —seronegative men remained close to 0 during the first year of infection. Conclusions. HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection. [ABSTRACT FROM AUTHOR]