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Insights into the Mechanism of Oral Tolerance Derived from the Study of Models of Mucosal Inflammation.
- Source :
- Annals of the New York Academy of Sciences; 2004, Vol. 1029 Issue 1, p115-131, 17p
- Publication Year :
- 2004
-
Abstract
- Murine models of mucosal inflammation are frequently due to the inability of the mouse to mount a regulatory T cell response. To the extent that such responses arise from oral tolerance mechanisms, these models provide a unique way of studying oral tolerance. In this paper we focus on the regulatory cells generated in two of the most well-studied of such models, the cell-transfer model and the TNBS-colitis model. Our analysis leads to the view that regulatory cells generated by the oral tolerance seen in mucosal inflammation are, at least in part, cells that recognize self-antigens or antigens in the mucosal microflora whose effector function relies on the expression of TGF-β. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
IMMUNITY
IMMUNOGLOBULINS
LYMPHOCYTES
COLON diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1029
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25214565
- Full Text :
- https://doi.org/10.1196/annals.1309.029