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Different Effects of Novel Stressors on Sympathoadrenal System Activation in Rats Exposed to Long-Term Immobilization.
- Source :
- Annals of the New York Academy of Sciences; 2004, Vol. 1018 Issue 1, p113-123, 11p
- Publication Year :
- 2004
-
Abstract
- Activation of the sympathoadrenal system, evaluated by plasmalevels of epinephrine (E) and norepinephrine (NE) after exposure of rats to variousstressors, is well documented. However, response of rats exposed longtermto a homotypic stressor and then exposed once to a heterotypic novelstressor is poorly understood. In the present study, we examined changes inplasma levels of catecholamines (CA) and corticosterone (COR) of rats after asingle (2-h) or long-term repeated immobilization (41 times, 2 h daily) and inrats adapted to long-term immobilization exposed once to the novel stress ofcold exposure or insulin or 2-deoxy-D-glucose (2DG) administration. Longtermimmobilization produced a significant elevation of basal plasma COR butnot NE and E levels. Long-term immobilized rats exposed to insulin or 2DGshowed significant elevation of plasma CA and COR levels in comparison to theadministration to control rats. Exposure of long-term immobilized and controlrats to cold stress increased plasma NE and COR, whereas plasma E was notsignificantly changed. The exposure of long-term immobilized rats to a furthersingle immobilization (2 h) increased plasma CA levels, but, in naive controlrats, the single immobilization produced more pronounced increases. Thesedata suggest that rats exposed to homotypic long-term immobilization are ableto respond to heterotypic stressors by higher activation of the sympathoadrenalsystem as compared with the control, previously unstressed rats. Reduced plasmaCA levels in long-term immobilized rats exposed to homotypic stressor aremost probably due to an adaptation at the level of brain regulatory centers. [ABSTRACT FROM AUTHOR]
- Subjects :
- LABORATORY rats
ADRENALINE
BLOOD plasma
HYPOGLYCEMIC agents
CATECHOLAMINES
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1018
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25243791
- Full Text :
- https://doi.org/10.1196/annals.1296.013