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TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection.
- Source :
- Annals of the New York Academy of Sciences; 2005, Vol. 1063 Issue 1, p161-166, 6p
- Publication Year :
- 2005
-
Abstract
- The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll-like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild-type and TLR2<superscript>-/-</superscript> mice. C. burnetii organisms were similarly eliminated by wild-type and TLR2<superscript>-/-</superscript> mice. In contrast, the formation of granulomas, a marker for efficient cell-mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance. [ABSTRACT FROM AUTHOR]
- Subjects :
- COXIELLA burnetii
Q fever
IMMUNE response
GRANULOMA
RICKETTSIAL diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1063
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25253834
- Full Text :
- https://doi.org/10.1196/annals.1355.025