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Pharmacological Characterization of Melanocortin Receptors in Fish Suggests an Important Role for ACTH.
- Source :
- Annals of the New York Academy of Sciences; 2005, Vol. 1040 Issue 1, p337-339, 3p
- Publication Year :
- 2005
-
Abstract
- The melanocortin (MC) receptor subtypes have distinctive characteristic binding profiles. We found that the trout and Fugu MC4 receptors have similar affinity for α-MSH and β-MSH and a much higher affinity for ACTH than does the human MC4 receptor. The Fugu MC1 and the trout and Fugu MC5 receptors also have higher affinity for ACTH-derived peptides than α-, β-, or γ-MSH. It is tempting to speculate that ACTH-derived peptides may have played an important role as "original" ligands at the MC receptors, while the specificity of the different subtypes for the α-, β-, and γ-MSH peptides may have appeared at later stages during vertebrate evolution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00778923
- Volume :
- 1040
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25254079
- Full Text :
- https://doi.org/10.1196/annals.1327.055