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Detection of CD4+ T-cell antibodies in a patient with idiopathic CD4+ T lymphocytopenia and cryptococcal meningitis.
- Source :
- British Journal of Haematology; Oct2007, Vol. 139 Issue 1, p133-137, 5p, 2 Charts, 1 Graph
- Publication Year :
- 2007
-
Abstract
- Idiopathic CD4<superscript>+</superscript> T lymphocytopenia (ICL) is defined as a CD4<superscript>+</superscript> T-cell count <0·3 × 10<superscript>9</superscript>/l or <20% of the total T-cell count on two occasions in the absence of any immunodeficiency disorder or therapy associated with reduced CD4<superscript>+</superscript> T-cell count. Although several mechanisms of ICL have been reported, the pathophysiology is still largely unknown. This case report describes a patient who presented with cryptococcal meningitis and was subsequently discovered to meet the criteria for ICL. Flow cytometric analysis of the patient's peripheral blood mononuclear cells revealed antibodies coating a much larger proportion of his CD4<superscript>+</superscript> T cells (33·61%) than the CD4<superscript>+</superscript> T cells of normal donors (3·94 ± 1·77%). The reasons behind the development of these autoantibodies are explored. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 139
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 26516608
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2007.06781.x