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Magnetic and fluorescent multifunctional chitosan nanoparticles as a smart drug delivery system.
- Source :
- Nanotechnology; Oct2007, Vol. 18 Issue 40, p05102-05102, 1p
- Publication Year :
- 2007
-
Abstract
- An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined magnetic targeting, fluorescent imaging and stimulus-responsive drug release properties into one drug delivery system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) and pharmaceutical drugs were simultaneously incorporated into chitosan nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface properties and drug release behaviors. The system showed superparamagnetic and strong fluorescent properties, and was used as a controlled drug release vehicle, which showed pH-sensitive drug release over a long time. The composite magnetic and fluorescent chitosan nanoparticles are potential candidates as a smart drug delivery system. [ABSTRACT FROM AUTHOR]
- Subjects :
- MAGNETICS
CHITOSAN
NANOPARTICLES
DRUG delivery systems
Subjects
Details
- Language :
- English
- ISSN :
- 09574484
- Volume :
- 18
- Issue :
- 40
- Database :
- Complementary Index
- Journal :
- Nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26654415
- Full Text :
- https://doi.org/10.1088/0957-4484/18/40/405102