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Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes.
- Source :
- Diabetes Care; Oct2007, Vol. 30 Issue 10, p2447-2452, 6p, 1 Chart, 1 Graph
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE --To compare pharmacokinetics and pharmacodynamics of insulin analogs glargine and detemir, 24 subjects with type 1 diabetes (aged 38 ± 10 years, BMI 22.4 ± 1.6 kg/m², and A1C 7.2 ± 0.7%) were studied after a 2-week treatment with either glargine or detemir once daily (randomized, double-blind, crossover study). RESEARCH DESIGN AND METHODS -- Plasma glucose was clamped at 100 mg/dl for 24 h after subcutaneous injection of 0.35 unit/kg. The primary end point was end of action (time at which plasma glucose was >150 mg/dl). RESULTS -- With glargine, plasma glucose remained at 103 ± 3.6 mg/dl up to 24 h, and all subjects completed the study. Plasma glucose increased progressively after 16 h with detemir, and only eight subjects (33%) completed the study with plasma glucose < 180 mg/dl. Glucose infusion rate (GIR) was similar with detemir and glargine for 12 h, after which it decreased more rapidly with detemir (P < 0.001). Estimated total insulin activity (GIR area under the curve [AUC]<subscript>O-end of GIR</subscript>) was 1,412 ± 662 and 915 ± 225 mg/kg (glargine vs. detemir, P < 0.05), with median time of end of action at 24 and 17.5 h (glargine vs. detemir, P < 0.001). The antilipolytic action of detemir was lower than that of glargine (AUC free fatty acids<subscript>0-24</subscript> h 11 ± 1.7 VS. 8 ± 2.8 mmol/l, respectively, P < 0.001). CONCLUSIONS -- Detemir has effects similar to those of glargine during the initial 12 h after administration, but effects are lower during 12-24 h. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHARMACOKINETICS
PHARMACODYNAMICS
INSULIN
PEOPLE with diabetes
BLOOD sugar
DIABETES
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 30
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 27138357
- Full Text :
- https://doi.org/10.2337/dc07-0002