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Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology.
- Source :
- British Journal of Haematology; Dec2007, Vol. 139 Issue 5, p809-819, 11p, 4 Charts, 4 Graphs
- Publication Year :
- 2007
-
Abstract
- The 2001 World Health Organization classification scheme considers B-cell chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) in an aggregate category (CLL/SLL) because of shared clinicopathological features. We have estimated age-adjusted incidence rates (IRs) of CLL and SLL in the population-based Surveillance, Epidemiology and End Results Program in the United States to analyse patterns of CLL and SLL separately and jointly. Age-standardized to the 2000 US population, overall IRs were 3·83 per 100 000 person-years for CLL ( n = 15 676) and 1·31 for SLL ( n = 5382) during 1993–2004. Incidence of the combined entity, CLL/SLL, was 90% higher among males compared to females, and the male:female IR ratio was significantly higher for CLL (1·98) than for SLL (1·67). CLL/SLL IRs were 25% and 77% lower among Blacks and Asian/Pacific Islanders, respectively, compared to Whites. A significant reporting delay was evident for CLL but not for SLL, so that CLL/SLL temporal trends must be interpreted cautiously. CLL and SLL IRs increased exponentially with age among all gender/race groups, with CLL IRs increasing more steeply with advancing age than SLL. Avenues of future research include assessment of delayed- and under-reporting to cancer registries and exploration of race, gender, and age effects in epidemiological studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC lymphocytic leukemia
LYMPHOMAS
EPIDEMIOLOGY
B cells
DISEASE incidence
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 139
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 27476635
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2007.06856.x