Back to Search
Start Over
Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4+CD25+ regulatory T cells.
- Source :
- Cell Death & Differentiation; Dec2007, Vol. 14 Issue 12, p2076-2084, 9p, 5 Graphs
- Publication Year :
- 2007
-
Abstract
- CD4<superscript>+</superscript>CD25<superscript>+</superscript> regulatory T cells (Treg) are potent immunosuppressive cells active in controlling normal pathological immune responses. The mechanisms of this suppression have been investigated under various conditions. In this report, tumor necrosis factor-related apoptosis inducing ligand (TRAIL)/death receptor 5 (DR5) was explored as one of the pivotal factors for the suppression and cytotoxicity induced by CD4<superscript>+</superscript>CD25<superscript>+</superscript> Treg. Cell death was involved in the suppression induced by activated CD4<superscript>+</superscript>CD25<superscript>+</superscript> Treg in vitro. The induction of CD4<superscript>+</superscript> T cell death was not mediated by the CD95/CD95L pathway, but rather depended upon the upregulation of TRAIL in the Treg. Blocking the TRAIL/DR5 pathway resulted in a significant reduction of the suppressive activity as well as the cytotoxic effects of Treg in vitro. Activated Treg displayed TRAIL-dependent cytotoxicity against CD4<superscript>+</superscript> T cells in vivo. The prolonged survival of allogeneic skin grafts induced by Treg was inhibited by DR5-blocking antibodies. Our findings suggest that the TRAIL/DR5 pathway is one of the mechanisms used by Treg to regulate immune responses both in vitro and in vivo.Cell Death and Differentiation (2007) 14, 2076–2084; doi:10.1038/sj.cdd.4402220; published online 31 August 2007 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13509047
- Volume :
- 14
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Cell Death & Differentiation
- Publication Type :
- Academic Journal
- Accession number :
- 27501343
- Full Text :
- https://doi.org/10.1038/sj.cdd.4402220