Reproductive History, Infertility Treatment, and the Risk of Acute Leukemia in Children With Down Syndrome.

The article discusses the association of reproductive history and infertility treatment with the risk of acute leukemia in children with Down syndrome (DS) based on a study in the U.S. It states that children with DS have 10 to 20 times risk of developing acute leukemia compared to the general pediatric population. The study found an increased risk of acute myeloid leukemia (AML) among children whose parents had tried to become pregnant for a year or more. It concludes that the risk for AML may be increased in children with DS due to infertility.