Back to Search
Start Over
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use.
- Source :
- British Journal of Psychiatry; Nov2007, Vol. 191, p402-407, 6p, 2 Charts
- Publication Year :
- 2007
-
Abstract
- <bold>Background: </bold>Genetic variations might modify associations between schizophrenia and cannabis or tobacco use.<bold>Aims: </bold>To examine whether variants within the cannabinoid receptor (CNR1) and alpha(7) nicotinic receptor (CHRNA7) genes are associated with schizophrenia, and whether these effects vary according to cannabis or tobacco use. We also examined a putative interaction between cannabis and Val(158)Met within the catechol-O-methyltransferase gene (COMT).<bold>Method: </bold>Genotype effects of CHRNA7 and CNR1were studied in a case-control sample of 750 individuals with schizophrenia and 688 controls, with interactions for these genes studied in small subsamples. A case-only design of 493 ofthe schizophrenia group was used to examine interactions between cannabis use and COMT.<bold>Results: </bold>There was no evidence of association between schizophrenia and CNR1 (OR=0.97, 95% CI 0.82-1.13) or CHRNA7 (OR=1.07, 95% CI 0.77-1.49) genotypes, or of interactions between tobacco use and CHRNA7, or cannabis use and CNR1or COMT genotypes.<bold>Conclusions: </bold>Neither CNR1 nor CHRNA7 variation appears to alter the risk of schizophrenia. Furthermore, our results do not support the presence of different effects of cannabis use on schizophrenia according to variation within COMT. [ABSTRACT FROM AUTHOR]
- Subjects :
- SCHIZOPHRENIA
MARIJUANA abuse
TOBACCO
GENES
MENTAL illness
PSYCHIATRY
CHOLINERGIC receptors
CELL receptors
COMPARATIVE studies
DISEASE susceptibility
DUAL diagnosis
GENETIC polymorphisms
RESEARCH methodology
MEDICAL cooperation
PSYCHOLOGICAL tests
RESEARCH
RESEARCH funding
SMOKING
TRANSFERASES
EVALUATION research
CASE-control method
GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Volume :
- 191
- Database :
- Complementary Index
- Journal :
- British Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 27579449
- Full Text :
- https://doi.org/10.1192/bjp.bp.107.036129