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Programmed death-i concentration at the immunological synapse is determined by ligand affinity and availability.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 11/6/2007, Vol. 104 Issue 45, p17765-17770, 6p, 4 Graphs
- Publication Year :
- 2007
-
Abstract
- Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at the plasma membrane, near the Golgi and in the trans-Golgi network. Unlike CD28 and CTLA-4, PD-1 accumulation at the synapse is extensive only when T cells interact with dendritic cells (DC5) expressing high B7-DC levels. However, B7-H1 is also critically important, especially when the DC5 have little 87-DC. Despite this preference, B7-H1<superscript>-/-</superscript> DCs elicit greater cytokine secretion than B7-DC<superscript>-/-</superscript> DCs during T cell restimulation, possibly because they also express less B7-DC. PD-1 and CD28 have similar kinetics of synaptic accumulation, suggesting that the process involves T cell receptor-triggered cytoskeletal reorganization followed by ligand binding. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 104
- Issue :
- 45
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 27582119
- Full Text :
- https://doi.org/10.1073/pnas.0708767104