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Assessment of cancer immunotherapy outcome in terms of the immune response time features.
- Source :
- Mathematical Medicine & Biology: A Journal of the IMA; Sep2007, Vol. 24 Issue 3, p287-300, 14p
- Publication Year :
- 2007
-
Abstract
- A cytokine-based periodic immunotherapy treatment is included in a model of tumour growth with a delay. The effects of dose schedule are studied in the case of a weak immune system and a growing tumour. We find the existence of 'metastable' states (that may last for tens of years) induced by the treatment and also potentially adverse effects of the dosage frequency on the stabilization of the tumour. These two effects depend on the delay between the tumour growth and the immune system response, the cytokine dose burden, and other parameters considered in the model. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER immunotherapy
IMMUNE response
TUMOR growth
CYTOKINES
IMMUNE system
Subjects
Details
- Language :
- English
- ISSN :
- 14778599
- Volume :
- 24
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Mathematical Medicine & Biology: A Journal of the IMA
- Publication Type :
- Academic Journal
- Accession number :
- 27586982
- Full Text :
- https://doi.org/10.1093/imammb/dqm003