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Modeling sequence evolution with kernel methods.

Authors :
Bresco, Margherita
Turchi, Marco
De Bie, Tijl
Cristianini, Nello
Source :
Computational Optimization & Applications; Nov2007, Vol. 38 Issue 2, p281-298, 18p, 5 Diagrams, 5 Graphs
Publication Year :
2007

Abstract

We model the evolution of biological and linguistic sequences by comparing their statistical properties. This comparison is performed by means of efficiently computable kernel functions, that take two sequences as an input and return a measure of statistical similarity between them. We show how the use of such kernels allows to reconstruct the phylogenetic trees of primates based on the mitochondrial DNA (mtDNA) of existing animals, and the phylogenetic tree of Indo-European and other languages based on sample documents from existing languages. Kernel methods provide a convenient framework for many pattern analysis tasks, and recent advances have been focused on efficient methods for sequence comparison and analysis. While a large toolbox of algorithms has been developed to analyze data by using kernels, in this paper we demonstrate their use in combination with standard phylogenetic reconstruction algorithms and visualization methods. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09266003
Volume :
38
Issue :
2
Database :
Complementary Index
Journal :
Computational Optimization & Applications
Publication Type :
Academic Journal
Accession number :
27656040
Full Text :
https://doi.org/10.1007/s10589-007-9045-9