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Special regulatory T-cell review: T-cell dependent suppression revisited.
- Source :
- Immunology; Jan2008, Vol. 123 Issue 1, p33-39, 7p, 2 Diagrams, 2 Charts
- Publication Year :
- 2008
-
Abstract
- The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
IMMUNE response
IMMUNOSUPPRESSION
SUPPRESSOR cells
IMMUNE system
IMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 123
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27810772
- Full Text :
- https://doi.org/10.1111/j.1365-2567.2007.02772.x