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T-cell activation: Where the action's at.
- Source :
- Nature Reviews Immunology; Feb2008, Vol. 8 Issue 2, p88-88, 1p, 1 Color Photograph
- Publication Year :
- 2008
-
Abstract
- The article discusses several studies that shed light on the exact location of primary CD8<superscript>+</superscript> T-cell activation in lymph nodes and on memory CD8<superscript>+</superscript> T-cell reactivation in peripheral tissues. It was found that infected cells can be seen in a continuous sheet below the lymph node sub-capsular sinus (SCS) within 2-3 hours of virus inoculation. The studies also showed that antigen encounter in peripheral tissues can result in the reactivation of memory CD8<superscript>+</superscript> T-cells.
- Subjects :
- T cells
LYMPH nodes
LYMPHATICS
CELLS
VIRUSES
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 8
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28611451
- Full Text :
- https://doi.org/10.1038/nri2268