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Shaping and reshaping CD8+ T-cell memory.
- Source :
- Nature Reviews Immunology; Feb2008, Vol. 8 Issue 2, p107-119, 13p, 6 Diagrams
- Publication Year :
- 2008
-
Abstract
- The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8<superscript>+</superscript> T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8<superscript>+</superscript> T-cell generation. Here, we dissect the input signals that shape the characteristics of the memory CD8<superscript>+</superscript> T-cell response and discuss how manipulation of these signals has the potential to reshape CD8<superscript>+</superscript> T-cell memory and improve the efficacy of vaccination. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
CELLS
IMMUNE response
IMMUNIZATION
VACCINATION
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 8
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28611463
- Full Text :
- https://doi.org/10.1038/nri2251