Selective serotonin reuptake inhibitors in depression: the influence of 5-HTTLPR and STin2 on treatment effect.

A conference paper about the influence of two polymorphisms in the serotonin transporter gene, 5-HTTLPR and STin2, on selective serotonin reuptake inhibitor (SSRI) treatment outcome in major depression is presented. Results suggest that women with the 5-HTTLPR genotype and men with the STin2 10/10 genotype have a less favorable response to SSRI treatment in major depressive disorder.