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Disruption of IRS-2 causes type 2 diabetes in mice.
- Source :
- Nature; 2/26/1998, Vol. 391 Issue 6670, p900, 5p, 5 Color Photographs, 18 Black and White Photographs, 1 Diagram, 10 Graphs
- Publication Year :
- 1998
-
Abstract
- Presents research which showed that disruption of IRS-2 impairs both peripheral insulin signaling and pancreatic beta-cell function in mice. Symptoms of human type 2 diabetes; Role of insulin-receptor substrates (IRS proteins) in diabetes; Effects of disruption of IRS-2 in mice; Traits of IRS-2-deficient mice; Possibilities for human type 2 diabetes.
- Subjects :
- INSULIN receptors
TYPE 2 diabetes
PATHOLOGICAL physiology
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 391
- Issue :
- 6670
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 306427
- Full Text :
- https://doi.org/10.1038/36116