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Disruption of IRS-2 causes type 2 diabetes in mice.

Authors :
Withers, Dominic J.
Gutierrez, Julio Sanchez
Towery, Heather
Burks, Deborah J.
Jian-Ming Ren
Previs, Stephen
Zhang, Yitao
Bernal, Dolores
Pons, Sebastian
Shulman, Gerald I.
Bonner-Weir, Susan
White, Morris F.
Source :
Nature; 2/26/1998, Vol. 391 Issue 6670, p900, 5p, 5 Color Photographs, 18 Black and White Photographs, 1 Diagram, 10 Graphs
Publication Year :
1998

Abstract

Presents research which showed that disruption of IRS-2 impairs both peripheral insulin signaling and pancreatic beta-cell function in mice. Symptoms of human type 2 diabetes; Role of insulin-receptor substrates (IRS proteins) in diabetes; Effects of disruption of IRS-2 in mice; Traits of IRS-2-deficient mice; Possibilities for human type 2 diabetes.

Details

Language :
English
ISSN :
00280836
Volume :
391
Issue :
6670
Database :
Complementary Index
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
306427
Full Text :
https://doi.org/10.1038/36116