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Interleukin-4 receptor α gene variants and allergic disease.
- Source :
- Respiratory Research; 2000, Vol. 1, p6-3, 3p, 1 Chart
- Publication Year :
- 2000
-
Abstract
- The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor α (IL-4Rα) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Rα polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERLEUKINS
ASTHMA
GENETIC polymorphisms
CELL receptors
GENES
ATOPY
Subjects
Details
- Language :
- English
- ISSN :
- 14659921
- Volume :
- 1
- Database :
- Complementary Index
- Journal :
- Respiratory Research
- Publication Type :
- Academic Journal
- Accession number :
- 30729331
- Full Text :
- https://doi.org/10.1186/rr3