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HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
- Source :
- Retrovirology; 2005, Vol. 2, p1-4, 4p
- Publication Year :
- 2005
-
Abstract
- The Tat protein of HIV-1 is a powerful activator of viral gene expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a remarkable number of other biological activities, among which the induction of cellular apoptosis. Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV
HIV infections
VIRAL genetics
GENE expression
VIROLOGY
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 2
- Database :
- Complementary Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 30739576
- Full Text :
- https://doi.org/10.1186/1742-4690-2-7