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SNFing HIV transcription.
- Source :
- Retrovirology; 2006, Vol. 3, p49-3, 3p, 1 Diagram
- Publication Year :
- 2006
-
Abstract
- The SWI/SNF chromatin remodeling complex is an essential regulator of transcription of cellular genes. HIV-1 infection induces exit of a core component of SWI/SNF, Ini1, into the cytoplasm and its association with the viral pre-integration complex. Several recent papers published in EMBO Journal, Journal of Biological Chemistry, and Retrovirology provide new information regarding possible functions of Ini1 and SWI/SNF in HIV life cycle. It appears that Ini1 has an inhibitory effect on pre-integration steps of HIV replication, but also contributes to stimulation of Tat-mediated transcription. This stimulation involves displacement of the nucleosome positioned at the HIV promoter. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections
GENETIC transcription
HIV
CHROMATIN
CYTOPLASM
GENES
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 3
- Database :
- Complementary Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 30740403
- Full Text :
- https://doi.org/10.1186/1742-4690-3-49