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The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction.

Authors :
Guller, Seth
Ma, Yula Y.
Fu, Han‐Hsuan
Krikun, Graciela
Abrahams, Vikki M.
Mor, Gil
Source :
Annals of the New York Academy of Sciences; Apr2008, Vol. 1127, p129-133, 5p, 3 Diagrams
Publication Year :
2008

Abstract

Preeclampsia is associated with an increased release of factors from the placental syncytium into maternal blood, including the antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluable endoglin, the antifibrinolytic factor plasminogen activator inhibitor-1, prostanoids, lipoperoxides, cytokines, and microparticles. These factors are suggested to promote maternal endothelium dysfunction and are associated with placental damage in pregnancies also complicated with intrauterine growth restriction (IUGR). In this report, we briefly describe the interaction of syncytial factors with hypoxia, reactive oxygen species, and apoptosis in the pathophysiology of preeclampsia and IUGR. Given the critical role of the syncytium in these complications of pregnancy, we also present a novel methodology in which laser capture microdissection followed by Western blotting is used to assess levels of syncytial Fas ligand, a key protein in the apoptotic cascade. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00778923
Volume :
1127
Database :
Complementary Index
Journal :
Annals of the New York Academy of Sciences
Publication Type :
Academic Journal
Accession number :
31688244
Full Text :
https://doi.org/10.1196/annals.1434.015