Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats.

The article presents two experiments which sought to determine the time course of changes of nedaplatin (NDP)-induced nephrotoxicity and to examine whether hydration is useful for amelioration of nephrotoxicity. The first experiment employed eight-week-old male rats, while the second experiment used nonhydrated (Nhyd) or hydrated (Hyd) rats treated with NDP. Results of the experiments suggested that NDP has the potential risk to cause nephrotoxicity at a human therapeutic dose without hydration and that pre- and post-hydration at dosing can enhance this nephrotoxicity.