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Dense deposit disease and the factor H H402 allele.
- Source :
- Clinical & Experimental Nephrology; Jun2008, Vol. 12 Issue 3, p228-232, 5p, 4 Black and White Photographs, 1 Diagram
- Publication Year :
- 2008
-
Abstract
- Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II). He was treated with alternate-day oral corticosteroids, angiotensin-converting enzyme (ACE) inhibitors and tacrolimus. Factor H mutational analysis showed the Y402H and I62V allele polymorphisms. The purpose of our report is to discuss the association of the H402 allele variant of factor H with the DDD/MPGN II phenotype and its possible therapeutic implications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13421751
- Volume :
- 12
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 32021743
- Full Text :
- https://doi.org/10.1007/s10157-008-0031-z