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Cyclosporin A Up-regulates B7-DC Expression on Dendritic Cells in an IL-4-dependent Manner In Vitro, Which is Associated with Decreased Allostimulatory Capacity of Dendritic Cells.
- Source :
- Immunopharmacology & Immunotoxicology; May2008, Vol. 30 Issue 2, p399-409, 11p, 2 Charts, 3 Graphs
- Publication Year :
- 2008
-
Abstract
- In addition to the effects on T lymphocytes, Cyclosporin A can inhibit dendritic cells allostimulatory capacity, but its precise mechanism remains unknown. The data in this study demonstrated that Cyclosporin A has no effect on the expression of major histocompatibility complex class II and costimulatory molecular CD80, CD86, CD40 on matured DC induced by Lipopolysaccharide in vitro, but can up-regulated B7-DC expression on DC in an Interleukin-4-dependent manner, which is associated with reduced allostimulatory ability of DC. Furthermore, Cyclosporin A treatment inhibited production of Interferon-γand TNF-α, Interleukin-12p70, but increased production of the Interleukin-10 of DC. Thus, up-regulated expression of B7-DC may be responsible for Cyclosporin A-mediated inhibitory effects on allostimulatory capacity of DC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 30
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 32706707
- Full Text :
- https://doi.org/10.1080/08923970701812746