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Severe Vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress and inflammation.
- Source :
- Free Radical Research; Jun2008, Vol. 42 Issue 6, p602-612, 11p, 1 Black and White Photograph, 4 Charts, 4 Graphs
- Publication Year :
- 2008
-
Abstract
- Hyperoxia causes acute lung injury along with an increase of oxidative stress and inflammation. It was hypothesized that vitamin E deficiency might exacerbate acute hyperoxic lung injury. This study used α-tocopherol transfer protein knockout (α-TTP KO) mice fed a vitamin E-deficient diet (KO E(-) mice) as a model of severe vitamin E deficiency. Compared with wild-type (WT) mice, KO E(-) mice showed a significantly lower survival rate during hyperoxia. After 72 h of hyperoxia, KO E(-) mice had more severe histologic lung damage and higher values of the total cell count and the protein content of bronchoalveolar lavage fluid (BALF) than WT mice. IL-6 mRNA expression in lung tissue and the levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) in both lungs and BALF were higher in KO E(-) mice than in WT mice. It was concluded that severe vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress or inflammation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10715762
- Volume :
- 42
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Free Radical Research
- Publication Type :
- Academic Journal
- Accession number :
- 32707347
- Full Text :
- https://doi.org/10.1080/10715760802189864