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Overexpression of AIB1 in Nasopharyngeal Carcinomas Correlates Closely With Advanced Tumor Stage.

Authors :
Meng-Zhong Liu
Dan Xie
Shi-Juan Mai
Zhu-Ting Tong
Jian-Yong Shao
Yong-Shui Fu
Wen-Jie Xia
Hsian-Fu Kung
Yi-Xin Zeng
Source :
American Journal of Clinical Pathology; May2008, Vol. 129 Issue 5, p728-734, 7p
Publication Year :
2008

Abstract

AIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51%) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24/35 [69%]) than in earlier stages (T1/T2, 12/36 [33%]; P 05). In addition, 18 (72%) of 25 NPCs with lymph node metastasis (N1-3) showed overexpression of AIB1; the frequency was significantly higher than that in NPCs without node metastasis (N0, 18/49 [39%]; P 05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029173
Volume :
129
Issue :
5
Database :
Complementary Index
Journal :
American Journal of Clinical Pathology
Publication Type :
Academic Journal
Accession number :
32805287
Full Text :
https://doi.org/10.1309/QMDTL82JKEX6E7H2