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The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
- Source :
- Breast Cancer Research & Treatment; Sep2008, Vol. 111 Issue 1, p139-144, 6p, 2 Charts, 1 Graph
- Publication Year :
- 2008
-
Abstract
- Abstract  A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93–1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER research
ASIANS
BREAST cancer
CHROMOSOME polymorphism
HEALTH
Subjects
Details
- Language :
- English
- ISSN :
- 01676806
- Volume :
- 111
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Breast Cancer Research & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 33216503