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Peptide YY induces enterocyte proliferation in a rat model with total enteral nutrition after distal bowel resection.
- Source :
- Pediatric Surgery International; Aug2008, Vol. 24 Issue 8, p913-919, 7p, 2 Black and White Photographs, 2 Charts, 5 Graphs
- Publication Year :
- 2008
-
Abstract
- The main reason why enterocyte proliferative effects of peptide YY (PYY) have not been detected in rats undergoing massive small intestinal resection after feeding may have been the background activity of markedly increased endogenous PYY released from L cells in the distal gut in response to the intraluminal nutrients. The purpose of the present study was to evaluate the effects of PYY on enterocyte proliferation in a rat model of distal bowel resection (DBR) with total enteral nutrition (TEN). Male, adult Sprague-Dawley rats were assigned into three experimental groups: sham rats underwent bowel transection and reanastomosis, DBR rats underwent the resection of 40 cm distal small intestine and colon, and DBR-PYY rats underwent distal bowel resection as above, and were treated with PYY(1-36) from day 2 to day 14 postoperatively. During days 2-14 postoperatively, all animals received isocaloric TEN. At the endpoints, plasma PYY levels and parameters of enterocyte proliferation were determined. Compared with the sham group, DBR rats demonstrated a significant decrease in plasma PYY levels, and a significant increase in intestinal bowel and mucosal weight, mucosal DNA and protein content, villus height and crypt depth, and crypt cell proliferation index. Administration of PYY (DBR-PYY group) led to a significant increase in plasma PYY levels, intestinal bowel and mucosal weight, mucosal DNA and protein content, villus height and crypt depth, and crypt cell proliferation index in comparison with the DBR untreated group. We conclude that administration of PYY increases the plasma PYY levels, and PYY induces enterocyte proliferation with TEN after distal bowel resection. [ABSTRACT FROM AUTHOR]
- Subjects :
- PEPTIDES
ORGANIC compounds
PEPTIDE hormones
AMINO acids
MEDICAL sciences
SMALL intestine surgery
ANIMAL experimentation
BIOLOGICAL models
CELL physiology
COMPARATIVE studies
ENTERAL feeding
EPITHELIAL cells
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
POSTOPERATIVE period
RADIOIMMUNOASSAY
RATS
RESEARCH
EVALUATION research
TREATMENT effectiveness
SHORT bowel syndrome
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 01790358
- Volume :
- 24
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Pediatric Surgery International
- Publication Type :
- Academic Journal
- Accession number :
- 33379612
- Full Text :
- https://doi.org/10.1007/s00383-008-2176-y