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Synthesis and anti-HIV-1 activity of S -dihydro(alkyloxy)benzyloxypyrimidine derivatives.
- Source :
- Chemical Monthly / Monatshefte für Chemie; Aug2008, Vol. 139 Issue 8, p967-974, 8p
- Publication Year :
- 2008
-
Abstract
- Abstract  Several 2-heteroaryl-, 2-heteroarylcarbonylmethyl-, 2-arylcarbonylmethyl, and 2-arylethyl derivatives of S-dihydro(alkyloxy)benzyloxypyrimidines have been synthesized and the anti-HIV activities of these compounds were tested in C8166 cell and against RT enzyme. It was found that some of these compounds showed good activity against HIV-1 (EC 50 = 0.014â0.8âμM) with low toxicity (CC 50 value of 222â564âμM) and high selectivity (SI value of 278â37743). The structure-activity relationships (SAR) of these compounds have also been discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00269247
- Volume :
- 139
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Chemical Monthly / Monatshefte für Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 33396964
- Full Text :
- https://doi.org/10.1007/s00706-007-0834-8