Association of Plasma Adiponectin Levels with Oxidative Stress in Hemodialysis Patients.

AbstractBackground:Recent evidence suggests that oxidative stress may be an instigator of the metabolic syndrome, and adiponectin, an adipocyte-derived polypeptide, may modulate oxidative stress, ameliorating the atherosclerotic process. Aim:Oxidative stress is increased in hemodialysis (HD) patients. We hypothesize that a relationship between plasma levels of adiponectin and markers of inflammation and oxidative stress exists. Methods and Results:In 124 HD patients, plasma adiponectin levels and three separate oxidative stress markers, tumor necrosis factor-? as well as high-sensitivity C-reactive protein (hsCRP) were determined. Plasma adiponectin was significantly and negatively correlated with serum hsCRP (r = –0.247, p = 0.008) and plasma malondialdehyde (MDA) levels (r = –0.326; p < 0.001). Multiple regression analyses suggested that plasma MDA, serum HDL cholesterol levels and logarithmically transformedhsCRP were the variables independently associated with plasma adiponectin levels. Conclusion:Plasma adiponectin was significantly associated with plasma MDA, serum HDL cholesterol levels and serum hsCRP levels. Our results suggest the possibility that plasma adiponectin may play a role in alleviating oxidative stress in HD patients.Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]