Rationally Designing Molecularly Imprinted Polymer Toward a High Specific Recognition by Using a Stoichiometric Self-Assembly.

This article presents an original work aimed at rationally designing a molecularly imprinted polymer capable of a high specific recognition. Assembling with Bisphenol A as template and acrylamide as functional monomer, the imprinted polymer was prepared. The results indicate that the use of stoichiometric self-assembly plays an obvious role on significantly increasing the specificity of prepared material, so as to better discriminate the template from its analogue. A higher or lower extent of molecular self-assembly would result in a dramatic decrease in this specificity. Related information indicates that this, logically, can be a result of the increasing match between binding sites and the template, which makes the polymer capable of specifically recognizing the imprint species. [ABSTRACT FROM AUTHOR]